| Identification | Back Directory | [Name]
Urea, N-cyclopropyl-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]- | [CAS]
1144075-40-0 | [Synonyms]
mTOR inhibitor 9e
1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-cyclopropylurea
Urea, N-cyclopropyl-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]- | [Molecular Formula]
C22H23N5O2S | [MOL File]
1144075-40-0.mol | [Molecular Weight]
421.52 |
| Hazard Information | Back Directory | [Uses]
mTOR inhibitor-17 (Compound 9e) is a selective inhibitor for mTOR. mTOR inhibitor-10 inhibits mTOR and PI3K-α, with IC50 of 0.68 and 1359 nM. mTOR inhibitor-10 inhibits proliferation of LNCaP with IC50 of 40 nM[1]. | [IC 50]
mTOR: 0.68 nM (IC50); PI3Kα: 1359 nM (IC50) | [References]
[1] Verheijen JC, et al., Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9. DOI:10.1016/j.bmcl.2009.10.075 |
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