ChemicalBook--->CAS DataBase List--->114420-56-3

114420-56-3

114420-56-3 Structure

114420-56-3 Structure
IdentificationBack Directory
[Name]

CLODINAFOP
[CAS]

114420-56-3
[Synonyms]

Cga 193469
CLODINAFOP
(R)-Clodinafop
CLODINAFOP15%WP
Clodinafop [iso]
clodinafop free acid
Clodinafop@100 μg/mL in Methanol
Clodinafop free acid Solution, 1000ppm
Clodinafop Solution in Methanol, 100μg/mL
(R)-2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propanoic Acid
(2R)-2-[4-[(5-Chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propanoic Acid
Propanoic acid, 2-(4-((5-chloro-3-fluoro-2-pyridinyl)oxy)phenoxy)-, (2R)-
[Molecular Formula]

C14H11ClFNO4
[MDL Number]

MFCD08273808
[MOL File]

114420-56-3.mol
[Molecular Weight]

311.69
Chemical PropertiesBack Directory
[Melting point ]

211-212℃
[Boiling point ]

410.2±45.0 °C(Predicted)
[density ]

1.407
[storage temp. ]

0-6°C
[solubility ]

Chloroform (Slightly), Ethyl Acetate (Slightly)
[form ]

Solid
[pka]

3.12±0.10(Predicted)
[color ]

White to Off-White
[EPA Substance Registry System]

Propanoic acid, 2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]-, (2R)- (114420-56-3)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
[Signal word ]

Warning
[Hazard statements ]

H319-H302-H411
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Description]

Clodinafop is a herbicide for annual grass weed control usually used as the propargyl variant. It is not expected to be persistent in soil systems but, under certain conditions it can be persistent in aquatic systems. Based on its physico-chemical properties it may leach to groundwater. Based on the data available it is moderately toxic to most biodiversity. It may be a mammalian reproduction/developmental toxin.
[Uses]

(R)-Clodinafop is used as herbicides for weed control in wheat.
[Definition]

ChEBI: An aromatic ether that is (R)-lactic acid in which the hydroxy group at position 2 has been converted to the corresponding p-[(5-chloro-3-fluoropyridin-2-yl)oxy]phenyl ether. It is the parent acid of the herbicide clodinafop-p opargyl.
[Production Methods]

Clodinafop is commercially produced through a multi-step synthesis that constructs its chiral aryloxyphenoxypropionic acid structure. The process typically begins with the preparation of a chloro-fluoro-substituted pyridine derivative, which is then coupled with a phenol intermediate via etherification to form the aryloxy linkage. This is followed by esterification or amidation with (R)-lactic acid or its derivatives to introduce the propanoic acid moiety with the desired stereochemistry and produce final product, clodinafop.
[Mechanism of action]

Systemic, contact acting. Acetyl CoA carboxylase inhibitor (ACCase) - distrupts fatty acid biosynthesis and lipid formation.
[Pesticide Type]

Herbicide; Metabolite; Plant Growth Regulator
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