| Identification | Back Directory | [Name]
BRUSATOL | [CAS]
114420-67-6 | [Synonyms]
BRUSATOL
Regaloside B
β-D-Glucopyranoside, (1S)-2-(acetyloxy)-1-[[[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]methyl]ethyl | [Molecular Formula]
C26H32O11 | [MDL Number]
MFCD01746220 | [MOL File]
114420-67-6.mol | [Molecular Weight]
442.41 |
| Chemical Properties | Back Directory | [Boiling point ]
727.5±60.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.58±0.15(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C20H26O11/c1-11(22)28-9-14(30-20-19(27)18(26)17(25)15(8-21)31-20)10-29-16(24)7-4-12-2-5-13(23)6-3-12/h2-7,14-15,17-21,23,25-27H,8-10H2,1H3 | [InChIKey]
YQKQOLPNKNHLBO-UHFFFAOYSA-N | [SMILES]
O(C1C(C(O)C(O)C(CO)O1)O)C(COC(=O)C)COC(=O)C=CC1C=CC(O)=CC=1 | [CAS DataBase Reference]
114420-67-6 |
| Questions And Answer | Back Directory | [Description]
Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte meiosis has not been addressed. |
| Hazard Information | Back Directory | [Uses]
Clinically, the research shows brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism, and it provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity. Brusatol overcomes chemoresistance through inhibition of protein translation. | [storage]
Store at -20°C |
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