| Identification | Back Directory | [Name]
Fantofarone | [CAS]
114432-13-2 | [Synonyms]
CS-2766
SR-33557
Fantofarone
FANTOFARONE;SR-33557;SR33557; 114432-13-2
2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine
3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine
Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]- | [Molecular Formula]
C31H38N2O5S | [MDL Number]
MFCD00867144 | [MOL File]
114432-13-2.mol | [Molecular Weight]
550.71 |
| Chemical Properties | Back Directory | [Melting point ]
82-83° | [density ]
dz 1.21 g/cm3 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
8.34 ± 0.05(at 25℃) | [color ]
Light yellow to yellow | [InChIKey]
ITAMRBIZWGDOHW-UHFFFAOYSA-N | [SMILES]
C1(CCN(C)CCCOC2=CC=C(S(C3=C4N(C=CC=C4)C=C3C(C)C)(=O)=O)C=C2)=CC=C(OC)C(OC)=C1 |
| Hazard Information | Back Directory | [Uses]
Fantofarone is a highly potent Calcium Channel antagonist. | [Biological Activity]
Fantofarone is a potent antagonist of Calcium Channels. | [in vitro]
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites. | [in vivo]
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective. | [storage]
Store at -20°C | [References]
[1] Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40. DOI:10.1016/s0006-2952(97)00482-6
[2] Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50. DOI:10.1016/s0006-2952(98)00026-4 |
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