| Identification | Back Directory | [Name]
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-(1-oxopropoxy)-, hydrate (1:3), (4S)- | [CAS]
1147090-70-7 | [Synonyms]
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-(1-oxopropoxy)-, hydrate (1:3), (4S)- | [Molecular Formula]
C23H20N2O5.3H2O | [Molecular Weight]
458.46 |
| Hazard Information | Back Directory | [Uses]
Camptothecin-20(S)-O-propionate (Camptothecin-20-O-propionate) hydrate, the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate hydrate is a topoisomerase-Ι inhibitor[1][2]. | [References]
[1] Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206. DOI:10.3892/br.2013.55
[2] Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. DOI:10.1158/0008-5472.CAN-08-4452 |
|
|