| Identification | Back Directory | [Name]
Cy7 | [CAS]
1151888-25-3 | [Synonyms]
FD-1080 Cl
FD-1080 Free Acid
4-(2-(2-(2-Chloro-3-(2-(1-(4-sulfobutyl)benzo[cd]indol-2(1H)-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)benzo[cd]indol-1-ium-1-yl)butane-1-sulfonate | [Molecular Formula]
C40H39ClN2O6S2 | [MOL File]
1151888-25-3.mol | [Molecular Weight]
743.33 |
| Hazard Information | Back Directory | [Uses]
FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging[1]. | [in vivo]
The 1064 nm NIR-II excitation of FD-1080 is demonstrated with the high tissue penetration depth and superior imaging resolution compared to NIR excitation from 650 nm to 980 nm. Deeptissue and high-resolution in vivo imaging for the left hindlimb vasculature, abdomen, and brain vessels was realized, allowing penetration through intact skin, tissue, and skull. FD-1080 also quantifying the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse[1]. | [References]
[1] Benhao Li, et al. An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging. Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7483-7487. DOI:10.1002/anie.201801226 |
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