| Identification | Back Directory | [Name]
D-PHE-PIP-ARG-PNA | [CAS]
115388-96-0 | [Synonyms]
S 2238;S2238
D-PHE-PIP-ARG-PNA
Chromogenix S-2765
D-PHE-PIP-ARG-PNA·2HCl
S-2238(Thrombin Substrate)
H-D-Phe-Pip-Arg-pNA acetate
D-Phe-Pip-Arg-pNA (Pippipecolyl)
Factor Xa Chromogenic Substrate 1
S 2238;S-2238;D-PHE-PIP-ARG-PNA·2HCL
S-2765,Chromogenic Substrate for Fxa
D-PHE-L-PIPECOLYL-ARG P-NITROANILIDE*TRI ACETATE
D-Phe-L-pipecolyl-Arg-p-nitroanilide dihydrochloride
H-D-Phe-Pip-Arg-pNA · 2 acetate, H-D-Phe-L-pipecolyl-Arg-pNA · 2 acetate | [Molecular Formula]
C27H36N8O5 | [MDL Number]
MFCD00083792 | [MOL File]
115388-96-0.mol | [Molecular Weight]
552.63 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
Solid | [color ]
White to yellow | [InChIKey]
YVHLNJUMPNYROS-IAYLHCNXNA-N | [SMILES]
C(=O)(O)C.C([C@@H]1CCCCN1C(=O)[C@H](N)CC1C=CC=CC=1)(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1C=CC(N(=O)=O)=CC=1 |&1:5,13,24,r| |
| Hazard Information | Back Directory | [Uses]
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform[1][2]. | [References]
[1] Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. DOI:10.1093/ajcp/73.5.639
[2] Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. PMID:6531759 |
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