| Identification | Back Directory | [Name]
CytochroMe P450 14a-deMethylase inhibitor 1b | [CAS]
1155361-00-4 | [Synonyms]
CytochroMe P450 14a-deMethylase inhibitor 1b
1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-[[[(2-fluorophenyl)methyl]-2-propen-1-ylamino]methyl]- | [Molecular Formula]
C21H21F3N4O | [MDL Number]
MFCD18384991 | [MOL File]
1155361-00-4.mol | [Molecular Weight]
402.41 |
| Hazard Information | Back Directory | [Uses]
CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively[1]. | [References]
[1] Chai X, et, al. Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Eur J Med Chem. 2009 May;44(5):1913-20. DOI:10.1016/j.ejmech.2008.11.007 |
|
|