| Identification | Back Directory | [Name]
BI-224436 | [CAS]
1155419-89-8 | [Synonyms]
BI 224436
BI-224436
3-Quinolineacetic acid, 4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-α-(1,1-dimethylethoxy)-2-methyl-, (αS,4R)- | [Molecular Formula]
C27H26N2O4 | [MDL Number]
MFCD28386552 | [MOL File]
1155419-89-8.mol | [Molecular Weight]
442.51 |
| Chemical Properties | Back Directory | [Boiling point ]
631.8±55.0 °C(Predicted) | [density ]
1.277±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: ≥ 50 mg/mL (112.99 mM) | [form ]
Powder | [pka]
0.81±0.30(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains. | [in vivo]
BI 224436 exhibits excellent pharmacokinetic profiles in rat (clearance as a percentage of hepatic flow [CL], 0.7%; bioavailability [F], 54%), monkey (CL, 23%; F, 82%), and dog (CL, 8%; F, 81%)[1]. | [storage]
Store at -20°C,unstable in solution, ready to use. | [References]
[1] Fenwick C, et al. Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor. Antimicrob Agents Chemother. 2014 Jun;58(6):3233-44. DOI:10.1128/AAC.02719-13 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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