| Identification | Back Directory | [Name]
CPNQ | [CAS]
115687-05-3 | [Synonyms]
B2
CPNQ
SIRT2 Inhibitor, B2
Linazolamide intermediate B impurity 2
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]- | [Molecular Formula]
C20H17ClN4O3 | [MDL Number]
MFCD02039810 | [MOL File]
115687-05-3.mol | [Molecular Weight]
396.83 |
| Chemical Properties | Back Directory | [Melting point ]
174-176°C | [Boiling point ]
645.5±55.0 °C(Predicted) | [density ]
1.412±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
H2O: insoluble <2mg/mL | [form ]
solid | [pka]
2.30±0.29(Predicted) | [color ]
brown | [Water Solubility ]
H2O: insoluble <2mg/mL
DMSO: >5mg/mL | [InChI]
1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2 | [InChIKey]
KLNPVNZJCWIQSK-UHFFFAOYSA-N | [SMILES]
[O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(Cl)cc3)c4cccnc14 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-36/37/38 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer. | [Definition]
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine. | [Biological Activity]
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity. | [IC 50]
SIRT2 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|