| Identification | Back Directory | [Name]
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride | [CAS]
1158264-69-7 | [Synonyms]
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride | [Molecular Formula]
C14H16ClN3O3 | [MDL Number]
MFCD31794744 | [MOL File]
1158264-69-7.mol | [Molecular Weight]
309.75 |
| Chemical Properties | Back Directory | [solubility ]
DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
Off-white to light yellow | [InChI]
InChI=1S/C14H15N3O3.ClH/c15-6-8-1-2-10-9(5-8)7-17(14(10)20)11-3-4-12(18)16-13(11)19;/h1-2,5,11H,3-4,6-7,15H2,(H,16,18,19);1H | [InChIKey]
XTILEMYXOZKSFJ-UHFFFAOYSA-N | [SMILES]
O=C1C2=CC=C(CN)C=C2CN1C1CCC(=O)NC1=O.Cl |
| Hazard Information | Back Directory | [Description]
3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride is used in the recruitment of the cereblon protein and used as a PROTAC linker. | [Uses]
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1] | [IC 50]
Cereblon | [References]
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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Abosyn Gold
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