| Identification | Back Directory | [Name]
N-Arachidonoyl Dopamine-d8 Exclusive | [CAS]
1159908-42-5 | [Synonyms]
N-Arachidonoyl Dopamine-d8 Exclusive
(5Z,8Z,11Z,14Z)-5,6,8,9,11,12,14,15-octadeuterio-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide | [Molecular Formula]
C28H33D8NO3 | [MOL File]
1159908-42-5.mol | [Molecular Weight]
447.679 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: Colloidal suspension @ 100 μg/,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,Ethanol:PBS (pH 7.2)(1:1): 100 μg/ml (colloidal suspensio |
| Hazard Information | Back Directory | [Uses]
N-Arachidonyldopamine-d8 is the deuterium labeled N-Arachidonyldopamine[1]. | [Biological Activity]
N-Arachidonoyl dopamine-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of N-arachidonoyl dopamine by GC- or LC-mass spectrometry. Several different arachidonoyl amino acids, including NADA, have been isolated and characterized from bovine brain.1 NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective cannabinoid agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA).2 NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 μM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA's endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.3 | [storage]
Store at -20°C | [References]
1.Huang, S.M., Bisogno, T., Petros, T.J., et al.Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits painThe Journal of Biological Chemisty276(46)42639-42644(2001)
2.Bisogno, T., Melck, D., Bobrov, M.Y., et al.N-acyl-dopamines: Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivoBiochem. J.351(Pt 3)817-824(2001)
3.Randall, M., and Maxey, K.M.Personal Communication(2003)
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