| Identification | Back Directory | [Name]
1-Boc-4-amino-4-piperidineacetic acid | [CAS]
1159983-30-8 | [Synonyms]
2-(4-Amino-1-(tert-butoxycarbonyl)
1-Boc-4-amino-4-piperidineacetic acid
2-(1-Boc-4-amino-4-piperidyl)acetic Acid
2-(4-Amino-1-boc-piperidin-4-yl)acetic Acid
2-(4-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)ACETIC ACID
4-Piperidineacetic acid, 4-amino-1-[(1,1-dimethylethoxy)carbonyl]-
2-[4-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]acetic acid | [Molecular Formula]
C12H22N2O4 | [MDL Number]
MFCD08460439 | [MOL File]
1159983-30-8.mol | [Molecular Weight]
258.31 |
| Chemical Properties | Back Directory | [Boiling point ]
398.9±27.0 °C(Predicted) | [density ]
1.158±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
4.66±0.10(Predicted) | [InChI]
InChI=1S/C12H22N2O4/c1-11(2,3)18-10(17)14-6-4-12(13,5-7-14)8-9(15)16/h4-8,13H2,1-3H3,(H,15,16) | [InChIKey]
BGBMNGXKKOJOSX-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(N)(CC(O)=O)CC1 |
| Hazard Information | Back Directory | [Uses]
1-Boc-4-amino-4-piperidineacetic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
A mixture of 4-oxo-piperidine- 1 -carboxylic acid tert-butyl ester (3.5 g, 17.55 mmol) (Sigma- Aldrich), malonic acid (2.0 g, 19.30 mmol) and ammonium acetate (3.1 g, 40.36 mmol) in n-BuOH was refluxed for 3 h. After cooled, white solid was collected, rinsed with EtOAc and dried in vacuo to provide the title compound 1.61 g (6.2 mmol) in 36% yield. | [References]
[1] Patent: WO2013/134660, 2013, A1. Location in patent: Paragraph 0373
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 10, p. 1071 - 1074 |
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Tetranov Biopharm
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13526569071 |
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http://www.leadmedpharm.com/index.html |
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Shanghai GL Peptide Ltd.
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+86-21-61263340; 17609490614 13764994101 |
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https://www.chemicalbook.com/supplier/10480342/ |
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Wuxi AppTec
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022-59987777 13552403979 |
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