| Identification | Back Directory | [Name]
Farnesyl Pyrophosphate Triammonium Salt | [CAS]
116057-57-9 | [Synonyms]
Farensyl Pyrophosphate D3 Triammonium Salt
Farnesyl Pyrophosphate Ammonium Salt, in Ethanol
DISCONTINUED. Please see F102470
(E,E)-Diphosphoric Acid Mono(3,7,11-triMethyl-2,6,10-dodecatrienyl) Ester TriaMMoniuM Salt
Diphosphoric Acid P-[(2E,6E)-3,7,11-TriMethyl-2,6,10-dodecatrien-1-yl] Ester AMMoniuM Salt | [Molecular Formula]
C15H37N3O7P2 | [MDL Number]
MFCD00189688 | [MOL File]
116057-57-9.mol | [Molecular Weight]
433.418 |
| Chemical Properties | Back Directory | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Methanol:NH4OH (70:30): * 1 mg/ml | [form ]
Solid | [color ]
White to Brown | [Stability:]
Hygroscopic, Light Sensitive, Temperature Sensitive |
| Hazard Information | Back Directory | [Description]
Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformations, FPP is a promiscuous ligand for a subset of nuclear receptors. | [Chemical Properties]
Pale Yellow Low Melting Solid | [Uses]
Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras. | [Uses]
Isoprenoid from the intracellular mevalonate pathway, Farnesyl Pyrophosphate Triammonium Salt can be used for prenylation of several low molecular mass G proteins, including Ras.
| [References]
[1] MCTAGGART S J. Isoprenylated proteins.[J]. Cellular and Molecular Life Sciences, 2006, 63 3: 255-267. DOI: 10.1007/s00018-005-5298-6
[2] CARL H?GBERG. Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y?? receptor-mediated platelet aggregation.[J]. Thrombosis and haemostasis, 2012, 108 1: 119-132. DOI: 10.1160/th11-10-0749
[3] TSUYOSHI GOTO. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.[J]. Biochemical Journal, 2011: 111-119. DOI: 10.1042/bj20101939
[4] RITU GOYANKA. Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.[J]. Protein Engineering Design & Selection, 2010, 23 11: 809-815. DOI: 10.1093/protein/gzq056 |
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