| Identification | Back Directory | [Name]
Carbonic acid, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl 4-nitrophenyl ester | [CAS]
1160640-95-8 | [Synonyms]
TSPO ligand-2
TSPO ligand-2,Inhibitor,TSPO ligand 2,Autophagy-targeting chimeras,AUTACs,inhibit,TSPO ligand2,TSPO ligand 2?,TSPO ligand2
Carbonic acid, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl 4-nitrophenyl ester | [Molecular Formula]
C23H29NO8 | [MOL File]
1160640-95-8.mol | [Molecular Weight]
447.48 |
| Hazard Information | Back Directory | [Uses]
TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells[1]. | [References]
[1] Takahashi D, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. DOI:10.1016/j.molcel.2019.09.009 |
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