| Identification | Back Directory | [Name]
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine | [CAS]
1160790-18-0 | [Synonyms]
[1,2,4]Triazolo[1,5-a]pyridine-6-boronic acid pinacol ester
[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLBORONIC ACID PINACOL ESTER
[1,2,4]Triazolo[1,5-a]pyridine-6-boronic acid pinacol ester 95%
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
[1,2,4]Triazolo[1,5-a]pyridine, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | [Molecular Formula]
C12H16BN3O2 | [MDL Number]
MFCD16659797 | [MOL File]
1160790-18-0.mol | [Molecular Weight]
245.09 |
| Chemical Properties | Back Directory | [Melting point ]
109-114°C | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
solid | [pka]
2.71±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
6-Bromo-[1,2,4]triazolo[1,5-A]pyridine (180 mg, 0.91 mmol) and pinacol ester of biphenylboronic acid (348 mg, 1.37 mmol) were added 1,1'-bis(diphenylphosphino)ferrocene palladium(II) (37 mg, 0.045 mmol) and potassium acetate (180 mg, 1.83 mmol) in tetrahydrofuran (10 mL). The reaction was carried out at 80 °C for 8 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature, filtered through diatomaceous earth and the solvent was evaporated under reduced pressure to afford [1,2,4]triazolo[1,5-a]pyridine-6-boronic acid pinacol ester (300 mg, yield: 74%). | [References]
[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0349; 0350; 0351
[2] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 36
[3] Patent: WO2010/20363, 2010, A1. Location in patent: Page/Page column 87-88 |
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Tetranov Biopharm
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13526569071 |
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www.leadmedpharm.com/index.html |
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