| Identification | Back Directory | [Name]
A 83586C | [CAS]
116364-81-9 | [Synonyms]
A 83586C
Antibiotic A-83586C
36-Deethyl-48-demethoxy-36-methylazinothricin | [Molecular Formula]
C47H76N8O14 | [MOL File]
116364-81-9.mol | [Molecular Weight]
977.152 |
| Hazard Information | Back Directory | [Description]
A 83586C is a depsipeptide antibiotic from Streptomyces karnatakensis that shows potent Gram-positive activity in vitro. It functions as a highly potent inhibitor of beta-cateniTCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A83586C antitumor cyclodepsipeptides also inhibit E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb). | [Uses]
A83586C is a new type of peptide antibiotic that is effective against Gram-positive bacteria[1]. | [References]
[1] SMITKA, T. A., et al. A83586C, a new depsipeptide antibiotic. The Journal of Antibiotics, 41(6), 726–733. |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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