| Identification | Back Directory | [Name]
2-amino-6-bromoanisole | [CAS]
116557-46-1 | [Synonyms]
3-Bromo-o-anisidine
2-amino-6-bromoanisole
3-Bromo-2-methoxybenzenamine
BenzenaMine, 3-broMo-2-Methoxy-
3-bromo-2-methoxyphenylamine hydrochloride
2-Amino-6-bromoanisole, 3-Bromo-o-anisidine | [EINECS(EC#)]
229-486-4 | [Molecular Formula]
C7H8BrNO | [MDL Number]
MFCD13186737 | [MOL File]
116557-46-1.mol | [Molecular Weight]
202 |
| Chemical Properties | Back Directory | [Melting point ]
65℃ | [Boiling point ]
268℃ | [density ]
1.531 | [refractive index ]
1.5430 to 1.5470 | [Fp ]
116℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
clear liquid | [pka]
3.46±0.10(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C7H8BrNO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,9H2,1H3 | [InChIKey]
ZLODWCIXZJMLJL-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=CC(Br)=C1OC |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 3-bromo-2-methoxyaniline from 2-bromo-6-nitroanisole was as follows: 1-bromo-2-methoxy-3-nitrobenzene (20.1 g, 86.6 mmol) was heated to 80 °C with iron powder (33.4 g, 598 mmol) in a solvent mixture of acetic acid/water (1:1, 600 mL). After the reaction lasted for 1.5 h, the mixture was cooled to room temperature and filtered. The filtered solid was washed several times with ethyl acetate and water. The organic layers were combined, washed with saturated aqueous NaHCO3, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 20:1 to 10:1) to afford 3-bromo-2-methoxyaniline as a yellow solid (17.4 g, 99% yield).1H-NMR (300 MHz, DMSO-d6) δ (ppm): 3.66 (s, 3H), 5.23 (s, 2H), 6.64-6.76 (m, 1H). 3H). | [References]
[1] Patent: EP2987787, 2016, A1. Location in patent: Paragraph 0131
[2] Patent: WO2014/74661, 2014, A1. Location in patent: Paragraph 00173
[3] Patent: US2014/296229, 2014, A1. Location in patent: Paragraph 0258; 0259
[4] Patent: WO2014/154760, 2014, A1. Location in patent: Page/Page column 55-56
[5] Patent: WO2018/75937, 2018, A1. Location in patent: Paragraph 00487; 00495; 00496 |
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