| Identification | Back Directory | [Name]
BUSULFAN-D8 (TETRAMETHYLENE-D8) | [CAS]
116653-28-2 | [Synonyms]
GT-41-d8
Myleran-d
Myleran-d8
CB-2041-d8
Misulban-d8
Busulfan-d8
Busulfex-d8
Busulphan-d8
Busulfan-D8(tetramethylene)
BUSULFAN-D8 (TETRAMETHYLENE-D8)
1,4-Butanediol-d8-dimethanesulfonate Esters | [Molecular Formula]
C6H6D8O6S2 | [MDL Number]
MFCD06658695 | [MOL File]
116653-28-2.mol | [Molecular Weight]
254.35 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
112-1140C | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 16.7 mg/ml,DMSO: 16.7 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3/i3D2,4D2,5D2,6D2 | [InChIKey]
COVZYZSDYWQREU-SQUIKQQTSA-N | [SMILES]
[S](=O)(=O)(OC(C(C(C(O[S](=O)(=O)C)([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C | [CAS Number Unlabeled]
55-98-1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Alkylating agent with antileukemic activity. Antineoplastic | [Description]
Busulfan-d8 is intended for use as an internal standard for the quantification of busulfan (Item No. 14843) by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.1 It forms both intra- and interstrand crosslinks on DNA.2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.4 | [References]
[1] APPELBAUM F. Is there a best transplant conditioning regimen for acute myeloid leukemia?[J]. Leukemia, 2000, 14 3: 497-501. DOI: 10.1038/sj.leu.2401601
[2] TAKUYA IWAMOTO. DNA intrastrand cross-link at the 5′-GA-3′ sequence formed by busulfan and its role in the cytotoxic effect[J]. Cancer Science, 2005, 95 5: 454-458. DOI: 10.1111/j.1349-7006.2004.tb03231.x
[3] M PONTI. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates[J]. British Journal of Cancer, 1991, 63 5: 743-747. DOI: 10.1038/bjc.1991.166
[4] E. COPELAN H D. Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation.[J]. Blood, 1992, 24 1: 1648-1658. DOI: 10.1182/blood.v80.7.1648.1648 |
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| Company Name: |
TOSUN PHARM
|
| Tel: |
61855200 13326451905 |
| Website: |
www.toref.cn/ |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|