| Identification | Back Directory | [Name]
INDY | [CAS]
1169755-45-6 | [Synonyms]
INDY
(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone
(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)- | [Molecular Formula]
C12H13NO2S | [MDL Number]
MFCD28100814 | [MOL File]
1169755-45-6.mol | [Molecular Weight]
235.3 |
| Chemical Properties | Back Directory | [Boiling point ]
409.2±45.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
9.67±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro. | [Uses]
INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2). | [in vivo]
ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo[1].
| [IC 50]
DYRK1A; DYRK1B | [storage]
-20°C | [References]
[1] YASUSHI OGAWA. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A[J]. Nature Communications, 2010, 1 1: 1-9. DOI: 10.1038/ncomms1090
[2] PENG WANG. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication[J]. Nature Medicine, 2015, 21 4: 383-388. DOI: 10.1038/nm.3820 |
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| Company Name: |
TaiChem Taizhou Limited
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| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
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