| Identification | Back Directory | [Name]
FW1256 | [CAS]
117089-08-4 | [Synonyms]
FW1256
1,3,2-Benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | [Molecular Formula]
C12H10NOPS | [MDL Number]
MFCD32690094 | [MOL File]
117089-08-4.mol | [Molecular Weight]
247.25 |
| Chemical Properties | Back Directory | [Melting point ]
139-142 °C | [Boiling point ]
376.3±25.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 250 mg/mL (1011.12 mM) | [form ]
Solid | [pka]
-0.88±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment[1][2]. | [in vivo]
FW1256 (100 mg/kg; intraperitoneal injection; male C57BL/6 mice) treatment reduces IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice[1]. | Animal Model: | Male C57BL/6 mice (20-25 g, 6-10 weeks) injected with E. coli lipopolysaccharide (LPS)[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Reduced IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.
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| [storage]
Store at -20°C | [References]
[1] Huang CW, et al. A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo. Pharmacol Res. 2016 Nov;113(Pt A):533-546. DOI:10.1016/j.phrs.2016.09.032
[2] Feng W, et al. Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity. J Med Chem. 2015 Aug 27;58(16):6456-80. DOI:10.1021/acs.jmedchem.5b00848 |
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MedChemExpress
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