1172118-03-4

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1172118-03-4 Structure

Identification	Back Directory
[Name] ACETAMIDE, N-[6-[4-AMINO-1-[[1,2-DIHYDRO-8-METHYL-2-(2-METHYLPHENYL)-1-OXO-3-ISOQUINOLINYL]METHYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]-2-BENZOTHIAZOLYL]-
[CAS] 1172118-03-4
[Synonyms] AK120464 HY-10549 AKOS016011504 CHEMBL2216897 AGN-PC-07162N PI3Ky inhibitor 1 PI3K3 inhibitor 1 MolPort-027-836-537 PI3K(gamma) inhibitor 1 INK-055 (PI3Kγ inhibitor 1) INK-055 (PI3K gamma inhibitor 1) PI-3Kγ inhibitor 1,PI3Kγ inhibitor 1 N-(6-(4-Amino-1-((8-methyl-1-oxo-2-(o-tolyl)-1,2-dihydroisoquinolin-3-yl)-methyl)-1H-pyrazolo[ N-(6-(4-Amino-1-((8-methyl-1-oxo-2-(o-tolyl)-1,2-dihydroisoquinolin-3-yl)-methyl)-1H-pyrazolo[3,4 PI3KΓ INHIBITOR 1; AGN-PC-07162N; CHEMBL2216897; MOLPORT-027-836-537; AKOS016011504; AK120464; HY-10549 PI3K&GAMMA;INHIBITOR 1; AGN-PC-07162N; CHEMBL2216897; MOLPORT-027-836-537; AKOS016011504; AK120464; HY-10549 N-(6-(4-Amino-1-((8-methyl-1-oxo-2-(o-tolyl)-1,2-dihydroisoquinolin-3-yl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide ACETAMIDE, N-[6-[4-AMINO-1-[[1,2-DIHYDRO-8-METHYL-2-(2-METHYLPHENYL)-1-OXO-3-ISOQUINOLINYL]METHYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]-2-BENZOTHIAZOLYL]-
[Molecular Formula] C32H26N8O2S
[MDL Number] MFCD18251458
[MOL File] 1172118-03-4.mol
[Molecular Weight] 586.67

Hazard Information	Back Directory
[Uses] PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.
[IC 50] PI3Kδ: 100 nM (IC₅₀); PI3Kγ: 100 nM (IC₅₀); PI3Kα: 10 μM (IC₅₀); PI3Kβ: 10 μM (IC₅₀)
[storage] Store at -20°C
[References] [1] Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.

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