| Identification | Back Directory | [Name]
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYLAMINO]-6-[2-[[2-(METHYLSULFONYL)ETHYL]AMINOMETHYL]-4-THIAZOLYL]QUINAZOLINE DIHYDROCHLORIDE | [CAS]
1173023-85-2 | [Synonyms]
GW 583340 DIHYDROCHLORIDE
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYLAMINO]-6-[2-[[2-(METHYLSULFONYL)ETHYL]AMINOMETHYL]-4-THIAZOLYL]QUINAZOLINE DIHYDROCHLORIDE
N-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYL]-6-[2-[[[2-(METHYLSULFONYL)ETHYL]AMINO]METHYL]-4-THIAZOLYL]-4-QUINAZOLINAMINE DIHYDROCHLORIDE | [Molecular Formula]
C28H27Cl3FN5O3S2 | [MDL Number]
MFCD07370137 | [MOL File]
1173023-85-2.mol | [Molecular Weight]
671.03 |
| Chemical Properties | Back Directory | [Melting point ]
259.8-262.4 °C(lit.) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 9 mg/mL | [form ]
solid | [InChIKey]
WIMITXDBYLKRKB-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2 |
| Hazard Information | Back Directory | [Uses]
GW 583340 dihydrochloride is a potent inhibitor of EGFR/ErbB2 reducing multi-drug resistance in cancer cells. Used in breast cancer treatment. | [Biological Activity]
Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active. | [storage]
Store at -20°C |
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Merck KGaA
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SIGMA-RBI
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