1173023-85-2

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1173023-85-2 Structure

Identification	Back Directory
[Name] 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYLAMINO]-6-[2-[[2-(METHYLSULFONYL)ETHYL]AMINOMETHYL]-4-THIAZOLYL]QUINAZOLINE DIHYDROCHLORIDE
[CAS] 1173023-85-2
[Synonyms] GW 583340 DIHYDROCHLORIDE 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYLAMINO]-6-[2-[[2-(METHYLSULFONYL)ETHYL]AMINOMETHYL]-4-THIAZOLYL]QUINAZOLINE DIHYDROCHLORIDE N-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYL]-6-[2-[[[2-(METHYLSULFONYL)ETHYL]AMINO]METHYL]-4-THIAZOLYL]-4-QUINAZOLINAMINE DIHYDROCHLORIDE
[Molecular Formula] C28H27Cl3FN5O3S2
[MDL Number] MFCD07370137
[MOL File] 1173023-85-2.mol
[Molecular Weight] 671.03

Chemical Properties	Back Directory
[Melting point ] 259.8-262.4 °C(lit.)
[storage temp. ] 2-8°C
[solubility ] DMSO: 9 mg/mL
[form ] solid
[InChIKey] WIMITXDBYLKRKB-UHFFFAOYSA-N
[SMILES] Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319-H335
[Precautionary statements ] P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ] Xi
[Risk Statements ] 36/37/38
[Safety Statements ] 26-36
[WGK Germany ] 3
[Storage Class] 11 - Combustible Solids
[Hazard Classifications] Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Hazard Information	Back Directory
[Uses] GW 583340 dihydrochloride is a potent inhibitor of EGFR/ErbB2 reducing multi-drug resistance in cancer cells. Used in breast cancer treatment.
[Biological Activity] Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYLAMINO]-6-[2-[[2-(METHYLSULFONYL)ETHYL]AMINOMETHYL]-4-THIAZOLYL]QUINAZOLINE DIHYDROCHLORIDE(1173023-85-2)¹HNMR

1173023-85-2 suppliers list

Company Name:	Hubei Yangxin Medical Technology Co., Ltd.
Tel:	15374522761
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Company Name:	Guangzhou Tuoshan Biotechnology Co., Ltd.
Tel:	19928332050
Website:	http://www.tuoshan.bio/

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