| Identification | Back Directory | [Name]
Alamandine | [CAS]
1176306-10-7 | [Synonyms]
Alamandine
Angiotensin A (1-7)
Angiotensin A (1-7) trifluoroacetate salt H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt | [Molecular Formula]
C40H62N12O9 | [MOL File]
1176306-10-7.mol | [Molecular Weight]
855 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.28±0.20(Predicted) | [color ]
White to off-white | [Sequence]
Ala-Arg-Val-Tyr-Ile-His-Pro |
| Hazard Information | Back Directory | [Uses]
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2]. | [Definition]
ChEBI: Alamandine is a peptide. | [Biochem/physiol Actions]
Alamandine is an endogenous heptapeptide that can be formed from angiotensin A by angiotensin converting enzyme-2 or directly from angiotensin-(1–7) by decarboxylation of its aspartate residue. Alamandine′s activity is similar to Ang-(1–7) rather than that of angiotensin II or angiotensin A. However, Alamandine acts at a different receptor, the Mas-related receptor, MrgD. Alamandine causes vasodilation, and has antifibrosis and antihypertensive activity. | [in vivo]
Alamandine (0.15 ?μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3]. | Animal Model: | Male spontaneously hypertensive rats (SHRs, 50-week-old)[3] | | Dosage: | 0.15 ?μL/h (~50 μg/kg/day) | | Administration: | Administered by mini-osmotic pumps; for 6 weeks | | Result: | Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function. |
| [storage]
Store at -20°C | [References]
[1] Daniel C Villela, et al. Alamandine: a new member of the angiotensin family. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4. DOI:10.1097/01.mnh.0000441052.44406.92
[2] Johanna Schleifenbaum. Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System. Front Med (Lausanne). 2019 Jun 11;6:107. DOI:10.3389/fmed.2019.00107
[3] Chi Liu, et al. Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats. Amino Acids. 2018 Aug;50(8):1071-1081. DOI:10.1007/s00726-018-2583-x |
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