| Identification | Back Directory | [Name]
1,9ALPHA,15S-TRIHYDROXY-PROST-13E-EN-11-ONE | [CAS]
1176470-37-3 | [Synonyms]
PROSTAGLANDIN D1 ALCOHOL
1,9ALPHA,15S-TRIHYDROXY-PROST-13E-EN-11-ONE
(2R,3R,4S)-4-hydroxy-3-(7-hydroxyheptyl)-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentan-1-one | [Molecular Formula]
C20H36O4 | [MDL Number]
MFCD00216040 | [MOL File]
1176470-37-3.mol | [Molecular Weight]
340.5 |
| Hazard Information | Back Directory | [Description]
Prostaglandin D1(PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl. There are no known reports of its biological activity. PGD1 is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.1 | [References]
1. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues J. Med. Chem. 26(6),790-799(1983). |
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