| Identification | Back Directory | [Name]
AL 8810 methyl ester | [CAS]
1176541-11-9 | [Synonyms]
AL 8810 methyl ester
SUQUNXDCROKALM-ZOXVUOEWSA-N
5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, methyl ester, (5Z)- | [Molecular Formula]
C25H33FO4 | [MOL File]
1176541-11-9.mol | [Molecular Weight]
416.53 |
| Chemical Properties | Back Directory | [Boiling point ]
554.5±50.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
14.21±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor. AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as latanoprost and travoprost. The pharmacology of AL 8810 methyl ester has not been published. | [Uses]
AL 8810 methyl ester is a prostaglandin F(2α) analog and a prostaglandin F(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines[1]. | [Definition]
ChEBI:AL 8810 methyl ester is a member of indanes. | [References]
[1] Griffin BW, et al. AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. PMID:10454504 |
|
|