| Identification | Back Directory | [Name]
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE | [CAS]
117690-79-6 | [Synonyms]
LY 255283
CGS 23356
5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone
1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE
Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]- | [Molecular Formula]
C19H28N4O3 | [MDL Number]
MFCD00876422 | [MOL File]
117690-79-6.mol | [Molecular Weight]
360.45 |
| Chemical Properties | Back Directory | [Melting point ]
160-162 °C | [Boiling point ]
573.4±60.0 °C(Predicted) | [density ]
1.157±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder | [pka]
5.11±0.10(Predicted) | [color ]
off-white to light yellow | [InChI]
1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23) | [InChIKey]
WCGXJPFHTHQNJL-UHFFFAOYSA-N | [SMILES]
CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2 |
| Hazard Information | Back Directory | [Description]
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM. | [Uses]
LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia. | [Definition]
ChEBI: 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone is an aromatic ketone. | [Biological Activity]
Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration. | [storage]
Store at +4°C | [References]
[1] STEVEN A. SILBAUGH . Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist[J]. European journal of pharmacology, 1992, 223 1: Pages 57-64. DOI: 10.1016/0014-2999(92)90818-o
[2] IVAN M. RICHARDS. Contribution of Leukotriene B4 to Airway Inflammation and the Effect of Antagonists[J]. Annals of the New York Academy of Sciences, 1991, 629 1: 274-287. DOI: 10.1111/j.1749-6632.1991.tb37983.x |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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