ChemicalBook--->CAS DataBase List--->1177154-51-6

1177154-51-6

1177154-51-6 Structure

1177154-51-6 Structure
IdentificationBack Directory
[Name]

BA, 3NH4
[CAS]

1177154-51-6
[Synonyms]

BA, 3NH4
BONGKREKIC ACID, TRIAMMONIUM SALT
3-CARBOXYMETHYL-17-METHOXY-6,18,21-TRIMETHYLDOCOSA-2,4,8,12,18,20-HEPTAENEDIOIC ACID
2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-[2-(aminooxy)-2-oxoethyl]-6-methoxy-2,5,17-trimethyl-, 1,22-diazanyl ester, (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-
[Molecular Formula]

C28H47N3O7
[MDL Number]

MFCD02179190
[MOL File]

1177154-51-6.mol
[Molecular Weight]

537.69
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[form ]

Beige to pink lyophilized solid.
Hazard InformationBack Directory
[Uses]

Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 μM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments.
[Biological Activity]

Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 μM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments.
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