| Identification | Back Directory | [Name]
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine | [CAS]
1180132-17-5 | [Synonyms]
Abemaciclib Impurity 4
LY2835219 Intermediate 1
-((4-Ethylpiperazin-1-yl)Methyl)pyridin-2-aMine
5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amin
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine
2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine
2-PyridinaMine, 5-[(4-ethyl-1-piperazinyl)Methyl]-
[5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl]amine
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine ISO 9001：2015 REACH | [EINECS(EC#)]
806-688-6 | [Molecular Formula]
C12H20N4 | [MDL Number]
MFCD14706690 | [MOL File]
1180132-17-5.mol | [Molecular Weight]
220.314 |
| Chemical Properties | Back Directory | [Boiling point ]
362℃ | [density ]
1.101 | [Fp ]
173℃ | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
7.71±0.10(Predicted) | [Appearance]
White to yellow Solid | [InChI]
InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14) | [InChIKey]
MNJBMPQTXVZMFZ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(CN2CCN(CC)CC2)C=C1 |
| Hazard Information | Back Directory | [Uses]
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine is a useful research chemical. | [Flammability and Explosibility]
Notclassified | [Synthesis]
To a 500 mL four-necked round-bottomed flask equipped with a thermometer and condenser tube were added 100 g of 1,2-dichloroethane, 12.5 g (0.1 mol) of 5-(aminomethyl)pyridin-2-amine (IV) and 30.0 g of potassium carbonate. A solution consisting of 25.0 g (0.15 mol) N,N-diethylethylamine and 20 g of 1,2-dichloroethane was added slowly and dropwise over a period of about 2 hours at 30 to 35 °C. The reaction temperature was maintained at 30~35°C and stirring was continued for 6 hours. After completion of the reaction, it was cooled to 20~25°C and layered. The aqueous layer was extracted twice with 1,2-dichloroethane at 20 g. The organic phases were combined and the 1,2-dichloroethane was removed by distillation. To the residue was added 75 g of methyl tert-butyl ether and 0.5 g of activated charcoal and stirred at 80~82°C for 1 hr. After hot filtration, the filtrate was cooled to 0~5°C for crystallization, filtered and dried to afford 18.2 g of 5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine as a white solid in 82.7% yield and 99.3% purity of the liquid phase. | [References]
[1] Patent: CN107337634, 2017, A. Location in patent: Paragraph 0040; 0053; 0054; 0057; 0058; 0061; 0062 |
|
|