| Identification | Back Directory | [Name]
H-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-OH | [CAS]
118068-30-7 | [Synonyms]
SNNFGAILSS
AMYLIN (20-29)
AMYLIN (20-29) (HUMAN)
AMYLIN FRAGMENT 20-29 HUMAN
SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER
H-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-OH
diabetes associated peptide fragment 20-29 human
H-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-OH USP/EP/BP
Amylin (20-29) (human) H-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-OH
L-Serine, L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl- | [Molecular Formula]
C43H68N12O16 | [MDL Number]
MFCD00080345 | [MOL File]
118068-30-7.mol | [Molecular Weight]
1009.07 |
| Hazard Information | Back Directory | [Uses]
Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2]. | [References]
[1] Kapurniotu A, et al. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol. 2002 Jan 18;315(3):339-50. DOI:10.1006/jmbi.2001.5244
[2] Elgersma RC, et al. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42. DOI:10.1016/j.bmcl.2007.01.042 |
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| Company Name: |
Ontores Biotech
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0571-88760729 18072970094 |
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www.ontoresinc.cn |
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