| Identification | Back Directory | [Name]
Dibenzofuran, 6-methyl-1,3,8-trichloro- | [CAS]
118174-38-2 | [Synonyms]
Dibenzofuran, 6-methyl-1,3,8-trichloro-
Dibenzofuran, 1,3,8-trichloro-6-methyl- | [Molecular Formula]
C13H7Cl3O | [MOL File]
118174-38-2.mol | [Molecular Weight]
285.55 |
| Hazard Information | Back Directory | [Uses]
AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1]. | [in vivo]
AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced[1]. | Animal Model: | C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old)[1] | | Dosage: | 0 mg/kg, 10 mg/kg, 40 mg/kg | | Administration: | Oral administration; daily; for 12 weeks | | Result: | The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced.
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| [References]
[1] Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1;77(7):1151-60. DOI:10.1016/j.bcp.2008.12.015
[2] Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5;21(39):6059-70. DOI:10.1038/sj.onc.1205633 |
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