| Identification | Back Directory | [Name]
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole mononitrate | [CAS]
118201-38-0 | [Synonyms]
Tetryzolin nitrate
Tetryzoline nitrate
TETRAHYDROZOLINE NITRATE
tetrahydrazoline nitrate
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazo...
2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole nitrate
nitric acid,2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole mononitrate
1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, mononitrate (9CI) | [Molecular Formula]
C13H17N3O3 | [MDL Number]
MFCD11973633 | [MOL File]
118201-38-0.mol | [Molecular Weight]
263.3 |
| Hazard Information | Back Directory | [Uses]
Tetrahydrozoline (Tetryzoline) nitrate , a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion[1][2]. | [Definition]
ChEBI: Tetrahydrozoline nitrate is an organic nitrate salt obtained by reaction of equimolar amounts of tetryzoline and nitric acid. It is used as a drug for the temporary relief of discomfort and redness of eyes due to minor eye irritations. It has a role as a vasoconstrictor agent, an ophthalmology drug and a sympathomimetic agent. It contains a tetryzoline(1+). | [References]
[1] E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190(40):E1208. DOI:10.1503/cmaj.180519
[2] Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol. 2010;603:501-8. DOI:10.1007/978-1-60761-459-3_49
[3] Danuta Nowakowska, et al. In vitro effects of vasoconstrictive retraction agents on primary human gingival fibroblasts. Exp Ther Med. 2020 Mar; 19(3): 2037-2044. DOI:10.3892/etm.2020.8462 |
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