| Identification | Back Directory | [Name]
Benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(chloromethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)- | [CAS]
118292-36-7 | [Synonyms]
pyrindamycin A
Duocarmycin C2
BOGFADYROAVVTF-MZHQLVBMSA-N
(2R)-8β-Chloromethyl-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-ylcarbonyl)benzo[1,2-b:4,3-b']dipyrrole-2α-carboxylic acid methyl ester
Benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(chloromethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)- | [Molecular Formula]
C26H26ClN3O8 | [MDL Number]
MFCD01659693 | [MOL File]
118292-36-7.mol | [Molecular Weight]
543.95 |
| Hazard Information | Back Directory | [Uses]
Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml[1]. | [References]
[1] Ishii S, et al. Antitumor activity of pyrindamycins A and B. J Antibiot (Tokyo). 1989 Nov;42(11):1713-7. DOI:10.7164/antibiotics.42.1713 |
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