| Identification | Back Directory | [Name]
AGN 190299 | [CAS]
118292-41-4 | [Synonyms]
CS-2016
AGN 190299
Tazarotene Acid
Tazarotenic acid
Tazarotenic acid (AGN 190299)
Tazarotenic Acid (10mM in DMSO)
Tazarotene Impurity 1（Tazarotenic Acid）
4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid
6-(4,4-Dimethyl-thiochroman-7-ylethynyl)-nicotinic acid
6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid
6-[[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran)-6-yl]ethynyl]nicotinic acid
6-[(4,4-diMethyl-3,4-dihydro-2H-thiochroMen-6-yl)ethynyl]pyridine-3-carboxylic acid
TAZAROTENIC ACID; 118292-41-4; 6-(2-(4;4-DIMETHYLTHIOCHROMAN-6-YL)ETHYNYL)NICOTINIC ACID
6-((3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-
6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridine carboxylic acid
3-Pyridinecarboxylicacid, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-
Tazarotenic Acid 13C2,D2Q: What is
Tazarotenic Acid 13C2,D2 Q: What is the CAS Number of
Tazarotenic Acid 13C2,D2 Q: What are the applications of
Tazarotenic Acid 13C2,D2 | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C19H17NO2S | [MDL Number]
MFCD00872121 | [MOL File]
118292-41-4.mol | [Molecular Weight]
323.41 |
| Chemical Properties | Back Directory | [Melting point ]
>190°C (dec.) | [Boiling point ]
527.5±50.0 °C(Predicted) | [density ]
1.31 | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
3.30±0.10(Predicted) | [color ]
Pale Yellow to Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Tazarotenic acid is the major active metabolite | [Uses]
Tazarotenic acid is the major active metabolite of Tazarotene (T010050). | [Uses]
The principle active metabolite | [Definition]
ChEBI: A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene. | [Biological Activity]
Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation.''Tazarotenic acidan active metabolite of tazaroteneis a potent and selective agonist of the retinoid receptor (RAR) th at binds to RARαRARβand RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1. | [in vivo]
Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1]
.
| Male | Female | Male | | Dose (mg kg-1) | 4.4 | 4.4 | 0.49 | | AUC (μg h mL-1) | 9.31 (2.14) | 9.78 (1.36) | 0.594 (0.95) | | CL (mL min-1 kg-1) | 7.96 (1.59) | 7.62 (0.85) | 14.0 (2.2) | | k (h-1) | 0.562 (0.339) | 0.820 (0.146) | 0.741 (0.115) | | T1/2 (h) | 1.64 (0.92) | 0.86 (0.14) | 0.95 (0.16) | | V0 (L kg-1)
| 0.43 (0.05) | 0.49 (0.06) | 1.31 (1.15) | | Vβ (L kg-1)
| - | - | 1.14 (0.09) | | Vmax (μg min-1)
| 9.08 (2.89) | 6.09 (1.22) | - | | Km (μg mL-1) | 7.09 (1.35) | 5.12 (1.19) | - |
| [storage]
Store at -20°C |
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