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118359-33-4

118359-33-4 Structure

118359-33-4 Structure
IdentificationBack Directory
[Name]

AMinopterin-α-hyrazide
[CAS]

118359-33-4
[Synonyms]

AMinopterin-α-hyrazide
Aminopterin-a-hyrazide
Aminopterin-α-hyrazide
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, 5-hydrazide
[Molecular Formula]

C19H22N10O4
[MDL Number]

MFCD31562442
[MOL File]

118359-33-4.mol
[Molecular Weight]

454.44
Chemical PropertiesBack Directory
[density ]

1.555±0.06 g/cm3(Predicted)
[pka]

3.56±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Aminopterin-α-hyrazide, is derivative of Aminopterin (A628850), which is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
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