ChemicalBook--->CAS DataBase List--->1184263-99-7

1184263-99-7

1184263-99-7 Structure

1184263-99-7 Structure
IdentificationBack Directory
[Name]

Lapatinib-d4
[CAS]

1184263-99-7
[Synonyms]

Lapatinib-d4
[Molecular Formula]

C29H26ClFN4O4S
[MOL File]

1184263-99-7.mol
[Molecular Weight]

581.06
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].
[storage]

Store at -20°C
[References]

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94. PMID:12467226
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