| Identification | Back Directory | [Name]
FLURBIPROFEN-D3 | [CAS]
1185133-81-6 | [Synonyms]
FLURBIPROFEN-D3
3-Fluoro-4-phenylhydratropic Acid-d3
2-Fluoro-α-(Methyl-d3)-4-diphenylacetic Acid
2-Fluoro-α-(Methyl-d3)-[1,1'-biphenyl]-4-acetic Acid
2-Fluoro-a-trideuteromethyl-[1,1biphenyl]-4-acetic Acid, | [Molecular Formula]
C15H13FO2 | [MDL Number]
MFCD09840635 | [MOL File]
1185133-81-6.mol | [Molecular Weight]
244.261 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
108-110°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.9 mg/ml | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
An Isotopically labeled analog of Flurbiprofe | [Uses]
An isotopically labelled analog of Flurbiprofen (F598700). | [Description]
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively). In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis. |
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| Company Name: |
TOSUN PHARM
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| Tel: |
020-61855200 13326451905 |
| Website: |
www.toref.cn/ |
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