| Identification | Back Directory | [Name]
Lapatinib (4-Methylbenzenesulfonate) | [CAS]
1187538-35-7 | [Synonyms]
GW2016 tosylate
Lapatinib (4-Methylbenzenesulfonate)
GW2016 tosylate|||GW572016 tosylate|||GW572016 tosylate | [Molecular Formula]
C36H34ClFN4O7S2 | [MDL Number]
MFCD21090418 | [MOL File]
1187538-35-7.mol | [Molecular Weight]
753.26 |
| Hazard Information | Back Directory | [Uses]
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. | [in vivo]
Lapatinib (GW2016; 30-100 mg/kg; oral administration; twice daily; for 21 days; CD-1 nude female mice) tosylate treatment inhibits tumor xenograft growth of the HN5 cells in a dose-responsive manner at 30 and 100 mg/kg, with complete inhibition of tumor growth at the higher dose[1]. | Animal Model: | CD-1 nude female mice (4-6 weeks old) with HN5 cells[1] | | Dosage: | 30 mg/kg, 100 mg/kg | | Administration: | Oral administration; twice daily; for 21 days | | Result: | Inhibited tumor xenograft growth of the HN5 cells in a dose-responsive manner. |
| [IC 50]
EGFR: 10.2 nM (IC50); ErbB2: 9.8 nM (IC50) |
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