| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide, 5-butyl-N2-(3-chloro-4-methylphenyl)-N6-cyclopentyl-4,5,6,7-tetrahydro-6-methyl-4-oxo- | [CAS]
1189710-20-0 | [Synonyms]
Pyrazolo[1,5-a]pyrazine-2,6-dicarboxamide, 5-butyl-N2-(3-chloro-4-methylphenyl)-N6-cyclopentyl-4,5,6,7-tetrahydro-6-methyl-4-oxo- | [Molecular Formula]
C25H32ClN5O3 | [MOL File]
1189710-20-0.mol | [Molecular Weight]
486.01 |
| Chemical Properties | Back Directory | [Boiling point ]
664.4±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.97±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SMIP34 is a PELP1 inhibitor. SMIP34 binds to PELP1 with a Kd of 37.4 μM. SMIP34 inhibits cancer cell proliferation and tumor progression. SMIP34 can be used for breast cancer research, and is active against wild-type (WT), mutant (MT) ER+ and therapy-resistant (TR)-ER+ breast cancer[1]. | [References]
[1] Altwegg KA, et al. A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer. Cancer Res. 2022 Oct 17;82(20):3830-3844. DOI:10.1158/0008-5472.CAN-22-0698 |
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