| Identification | Back Directory | [Name]
6-Fluoro-1H-pyrrolo[3,2-b]pyridine | [CAS]
1190320-33-2 | [Synonyms]
6-Fluoro-4-azaindole
6-Fluoro-1H-pyrrolo[3,2-b]pyridine
1H-Pyrrolo[3,2-b]pyridine, 6-fluoro- | [Molecular Formula]
C7H5FN2 | [MDL Number]
MFCD12962608 | [MOL File]
1190320-33-2.mol | [Molecular Weight]
136.13 |
| Chemical Properties | Back Directory | [Boiling point ]
277.6±20.0 °C(Predicted) | [density ]
1.370±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
14.06±0.40(Predicted) | [Appearance]
White to light brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 3: To a solution of 5-fluoro-2-((trimethylsilyl)alkynyl)pyridin-3-amine (2.22 g, 10.7 mmol) in N,N-dimethylformamide (DMF, 30 mL) was added sodium hydride (60% Mineral Oil Dispersion, 1.025 g, 42.7 mmol) in one batch at 0 °C and under nitrogen protection. After addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction solution was slowly poured into ice water and extracted with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO?), filtered and concentrated under reduced pressure to give 1.46 g of 6-fluoro-1H-pyrrolo[3,2-b]pyridine as a brown solid (100% yield). Mass spectrum (ESI): m/z = 137.2 [M + H]? | [References]
[1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 51
[2] Patent: WO2016/103037, 2016, A1. Location in patent: Paragraph 00631 |
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