| Identification | Back Directory | [Name]
2,4-DICHLORO-6,7-DIHYDRO-5H-PYRROLO[3,4-D]PYRIMIDINEHYDROCHLORIDE | [CAS]
1190927-74-2 | [Synonyms]
2,4-Dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine HCl
2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride
2,4-DICHLORO-6,7-DIHYDRO-5H-PYRROLO[3,4-D]PYRIMIDINEHYDROCHLORIDE
5H-Pyrrolo[3,4-d]pyrimidine, 2,4-dichloro-6,7-dihydro-, hydrochloride (1:1) | [Molecular Formula]
C6H6Cl3N3 | [MDL Number]
MFCD09835495 | [MOL File]
1190927-74-2.mol | [Molecular Weight]
226 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H5Cl2N3.ClH/c7-5-3-1-9-2-4(3)10-6(8)11-5;/h9H,1-2H2;1H | [InChIKey]
HQPWDHFFMDIBDT-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=C2CNCC2=N1.[H]Cl |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride using 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine as starting material was as follows: 284 mg of 6-Boc-2,4-dichloro-5,7-dihydropyrrolo[3,4-d]pyrimidine was dissolved in dichloromethane (DCM) , followed by the addition of 5.7 mL of 4 M hydrochloric acid in 1,4-dioxane solution. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the progress of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was concentrated and dried to give 250 mg of 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride as a beige solid powder in 93% yield. | [References]
[1] Patent: CN102584828, 2016, B. Location in patent: Paragraph 0117-0119
[2] Patent: WO2016/210331, 2016, A1. Location in patent: Paragraph 0317; 0318 |
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