| Identification | Back Directory | [Name]
H-LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 | [CAS]
119386-39-9 | [Synonyms]
KKRAARATS-NH2
MYOSIN KINASE INHIBITING PEPTIDE
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2
MYOSIN LIGHT CHAIN KINASE (11-19) AMIDE
H-LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-AMIDE
myosin light chain kinase fragment 11-19 amide
Myosin Light Chain Kinase Fragment 11-19 amide >=97% (HPLC)
L-Serinamide, L-lysyl-L-lysyl-L-arginyl-L-alanyl-L-alanyl-L-arginyl-L-alanyl-L-threonyl- | [Molecular Formula]
C40H78N18O11 | [MDL Number]
MFCD00076722 | [MOL File]
119386-39-9.mol | [Molecular Weight]
987.16 |
| Hazard Information | Back Directory | [Uses]
Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer[1][2]. | [References]
[1] Aromolaran AS, et al. Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes. J Physiol. 2000 May 1;524 Pt 3(Pt 3):853-63. DOI:10.1111/j.1469-7793.2000.00853.x
[2] Shen MR, et al. Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. Pflugers Arch. 2002 May;444(1-2):276-85. DOI:10.1007/s00424-002-0811-3
[3] Chilcoat CD, et al. Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase. J Leukoc Biol. 2008 Apr;83(4):964-71. DOI:10.1189/jlb.0405192 |
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