| Identification | Back Directory | [Name]
3-HYDROXY DESLORATADINE HCL | [CAS]
119410-08-1 | [Synonyms]
Sch 45581
3-OH-desloratadine-D4 Hbr
3-HYDROXY DESLORATADINE HCL
Desloratadine 3-Hydroxy Impurity
Loratadine Desethoxycarbonyl 3-Hydroxy IMpurity
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-β]pyridin-3-ol
8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
5H-Benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)- | [Molecular Formula]
C19H19ClN2O | [MDL Number]
MFCD08063736 | [MOL File]
119410-08-1.mol | [Molecular Weight]
326.82 |
| Chemical Properties | Back Directory | [Appearance]
Light Brown Solid | [Melting point ]
169-171°C | [Boiling point ]
575.2±50.0 °C(Predicted) | [density ]
1.292 | [storage temp. ]
-20?C Freezer, Under Inert Atmosphere | [solubility ]
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
9.27±0.20(Predicted) | [color ]
pale yellow to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
Light Brown Solid | [Uses]
An active metabolite of Loratadine | [Biological Activity]
3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadinea major active human metabolite. |
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