| Identification | Back Directory | [Name]
14(S)-Hydroxy Docosahexaenoic Acid | [CAS]
119433-37-3 | [Synonyms]
14(S)-HDHA
14(S) HDHA,14(S)HDHA
ZNEBXONKCYFJAF-OUKOMXQNSA-N
14(S)-Hydroxy Docosahexaenoic Acid
14(S)-hydroxy-4(Z),7(Z),10(Z),12(E),16(Z),19(Z)-docosahexaenoic acid
4,7,10,12,16,19-Docosahexaenoic acid, 14-hydroxy-, (4Z,7Z,10Z,12E,14S,16Z,19Z)- | [Molecular Formula]
C22H32O3 | [MOL File]
119433-37-3.mol | [Molecular Weight]
344.49 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.5 mg/ml |
| Hazard Information | Back Directory | [Description]
14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA; ). It is a precursor to the pro-resolving mediator maresin 1 and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis. | [Uses]
14(S)-Hydroxy Docosahexaenoic Acid is formed by human platelets. 14(S)-Hydroxy Docosahexaenoic Acid reacts with activated macrophages to form dihydroxy-containg products which posses potent antiinflammatory and proresolving activity. | [Uses]
Docosahexaenoic acid (DHA; ) is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-HDHA administration resulted in reduced infiltration of PMNs into sites of inflammation.[Cayman Chemical] | [Definition]
ChEBI:(14S)-HDoHE is a 14-HDoHE in which the stereocentre at position 14 has S-configuration. It is a conjugate acid of a (14S)-HDoHE(1-). It is an enantiomer of a (14R)-HDoHE. | [storage]
Store at -20°C |
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