| Identification | Back Directory | [Name]
TERT-BUTYL (3-IODOTHIOPHEN-2-YL)CARBAMATE | [CAS]
119485-56-2 | [Synonyms]
TERT-BUTYL (3-IODOTHIOPHEN-2-YL)CARBAMATE
Carbamic acid, N-(3-iodo-2-thienyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C9H12INO2S | [MOL File]
119485-56-2.mol | [Molecular Weight]
325.17 |
| Chemical Properties | Back Directory | [Melting point ]
42-44 °C | [Boiling point ]
299.6±25.0 °C(Predicted) | [density ]
1.711±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
12.84±0.70(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Example 2 Preparation of tert-butyl (3-iodothiophene-2-yl)carbamate: 3-iodothiophene-2-carboxylic acid (23.5 g, 0.10 mol) was mixed with triethylamine (15 mL, 1.1 eq.) to which was added a tert-butanol solution of diphenoxyphosphoryl azide (30 g, 1.1 eq.). The reaction mixture was heated at reflux temperature for 16 h and subsequently cooled to room temperature. The reaction mixture was washed with saturated Na2CO3 solution and extracted with EtOAc. The organic extracts were combined, dried with MgSO4 and concentrated under reduced pressure. The resulting residue was purified by column chromatography (eluent: 10% EtOAc in hexane solution) to give the title product as a brown solid (10.5 g, 35% yield). The product was characterized by HPLC and mass spectrometry. | [References]
[1] Patent: WO2005/12311, 2005, A1. Location in patent: Page/Page column 22 |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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