| Identification | Back Directory | [Name]
sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate | [CAS]
119515-38-7 | [Synonyms]
Bayrepe
KBR 3023
ICARIDIN
Bayrepel
Icaridine
Picaridin
BAYREPELVE
Picaridin, 93-97%
HYDROXYETHYL ISOBUTYL PIPERIDINE CARBOXYLATE
2-(2-hydroxyethyl)-1-piperidinecarboxylicacid 1-Me
sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate
1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine
1-methylpropyl2-(2-hydroxyethyl)-1-piperidinecarboxylate
1-(1-methyl-propoxycarbonyl)-2-(2-hydroxyethyl)-piperidine
2-(2-hydroxyethyl)-1-piperidinecarboxylicaci1-methylpropylester
2-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid 1-Methyl-propyl Ester
1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1-methylpropyl ester | [EINECS(EC#)]
423-210-8 | [Molecular Formula]
C12H23NO3 | [MDL Number]
MFCD01756488 | [MOL File]
119515-38-7.mol | [Molecular Weight]
229.32 |
| Chemical Properties | Back Directory | [Appearance]
Colorless Liquid | [Melting point ]
<-170° | [Boiling point ]
2800C | [density ]
d20 1.07 | [refractive index ]
nD20 1.4717 | [Fp ]
142°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
15.15±0.10(Predicted) | [color ]
Colourless | [Henry's Law Constant]
3.3×105 mol/(m3Pa) at 25℃, HSDB (2015) | [Cosmetics Ingredients Functions]
ANTIMICROBIAL | [InChI]
InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3 | [InChIKey]
QLHULAHOXSSASE-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)CC)=O)CCCCC1CCO | [CAS DataBase Reference]
119515-38-7 | [EPA Substance Registry System]
1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1-methylpropyl ester(119515-38-7) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless Liquid | [Uses]
Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources.
Insect repellent | [Uses]
Insect repellent. | [Hazard]
A reproductive hazard. | [Description]
Picaridin is an insect repellent.1,2,3 It inhibits A. aegypti odorant receptor 2 (AaOR2) or AaOR8 in the presence of their odorant activators, indole and octenol, respectively, expressed in Xenopus oocytes (IC50s = 1,452 and 1,911 μM, respectively).1 Picaridin reduces the number of entries into a food chamber by female D. melanogaster in an olfactory-based choice assay.2 It acts synergistically with the non-pyrethroid insecticide pyrimiphos methyl to increase mortality of A. gambiae and reduce blood feeding when used at a concentration of 10 g/m2 on nets surrounding guinea pig cages.3 Formulations containing picaridin have been used as insect repellents against flies, mosquitoes, chiggers, ticks, and fleas. | [Definition]
ChEBI: Butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a carboxylic acid and a member of piperidines. | [Production Methods]
Commercial production of icaridin involves a highly optimised chemical synthesis process developed to meet global demand for safe and effective insect repellents. The active ingredient is a piperidine derivative, and its synthesis typically starts with cyclohexane derivatives, which undergo a series of reactions including chlorination, etherification, and nitrile formation to build the final molecular structure. | [Mechanism of action]
Topically applied, repellent. Odorant receptor. It has been proposed that icaridin may bind to odorant binding protein 1 (AgamOBP1). | [storage]
4°C, protect from light | [References]
[1] JONATHAN D BOHBOT Joseph C D. Insect repellents: modulators of mosquito odorant receptor activity.[J]. PLoS ONE, 2010: e12138. DOI: 10.1371/journal.pone.0012138
[2] ZAINULABEUDDIN SYED. Generic insect repellent detector from the fruit fly Drosophila melanogaster.[J]. PLoS ONE, 2011: e17705. DOI: 10.1371/journal.pone.0017705
[3] CéDRIC PENNETIER. Synergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against Anopheles gambiae.[J]. ACS Applied Bio Materials, 2007: 38. DOI: 10.1186/1475-2875-6-38 | [Pesticide Type]
Insecticide; Repellent; Veterinary substance |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Tocopharm Co., Ltd.
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+86-021-69895597 13776836200 +86-13776836200 |
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http://www.tocopharm.com/ |
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