| Identification | Back Directory | [Name]
ZILPATEROL HYDROCHLORIDE | [CAS]
119520-05-7 | [Synonyms]
zilpa
RU-4217
RU-42173
trans-(±)-Zilpaterol
zilpaterol Solution, 100ppm
Zilpaterol HCl and Enantiomer
ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY)
ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY)
(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one
Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-
Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, (6R,7R)-rel- | [EINECS(EC#)]
924-535-2 | [Molecular Formula]
C14H19N3O2.ClH | [MDL Number]
29339900 | [MOL File]
119520-05-7.mol | [Molecular Weight]
297.784 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
123-126°C | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
13.39±0.60(Predicted) | [Stability:]
Temperature Sensitive | [CAS DataBase Reference]
119520-05-7 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
β-Adrenergic agonist. Growth promotant. | [Uses]
Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle. | [Definition]
ChEBI: Zilpaterol is a benzazepine. | [Biological Activity]
zilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes. | [in vitro]
previus study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1]. | [in vivo]
fda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2]. | [storage]
Store at -20°C | [References]
[1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012).
[2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010). |
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