| Identification | Back Directory | [Name]
7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% | [CAS]
119577-28-5 | [Synonyms]
Camptothecin Impurity 7
12-Ethyl-9-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin
4,7-Diethyl-10-hydroxycamptothecin
7-ETHYL-10-HYDROXYCAMPTOTHECIN,98%
7-Ethyl-10-hydroxycamptothecin 119577-28-5 For Human Health
(S)-4,7-Diethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,7-diethyl-4,10-dihydroxy-, (S)- (9CI)
(S)?-4,?7-Diethyl-?4,?10-?dihydroxy-1H-?pyrano[3',?4':6,?7]?indolizino[1,?2-?b]?quinoline-?3,?14(4H,?12H)?-?dione | [Molecular Formula]
C22H20N2O5 | [MDL Number]
MFCD06762720 | [MOL File]
119577-28-5.mol | [Molecular Weight]
392.4 |
| Chemical Properties | Back Directory | [Boiling point ]
813.7±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.08±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Camptotheca acuminata. | [Uses]
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. | [References]
[1] Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401. DOI:10.1021/jm00003a001 |
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