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1199236-64-0

1199236-64-0 Structure

1199236-64-0 Structure
IdentificationBack Directory
[Name]

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
[CAS]

1199236-64-0
[Synonyms]

Z-944
N-[[1-[2-(tert-butylamino)-2-
Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit
4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
[Molecular Formula]

C19H27ClFN3O2
[MDL Number]

MFCD27966181
[MOL File]

1199236-64-0.mol
[Molecular Weight]

383.89
Chemical PropertiesBack Directory
[Melting point ]

122-124°C
[Boiling point ]

528.1±50.0 °C(Predicted)
[density ]

1.166±0.06 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.65±0.46(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Description]

Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.
[Chemical Properties]

White Solid
[Uses]

As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.
[Definition]

ChEBI: Ulixacaltamide is a member of piperidines, a member of benzamides, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. It has a role as a T-type calcium channel blocker and a non-narcotic analgesic.
[storage]

Store at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide(1199236-64-0)1HNMR
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