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119942-75-5

119942-75-5 Structure

119942-75-5 Structure
IdentificationBack Directory
[Name]

Delequamine hydrochloride
[CAS]

119942-75-5
[Synonyms]

RS15385
RS-15385
RS 15385
Delequamine HCl
Delequamine hydrochloride
[Molecular Formula]

C18H27ClN2O3S
[MOL File]

119942-75-5.mol
[Molecular Weight]

386.94
Hazard InformationBack Directory
[Uses]

Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction[1].
[in vivo]

Delequamine (0.4-6.4 mg/kg; oral, single dose) hydrochloride can increase the sexual behavior score in a dose-dependent manner in a model where untrained male rats are exposed to estrogen-progesterone-treated, sexually receptive female rats. Furthermore, the combination of Delequamine (0.4 mg/kg; oral, single dose) hydrochloride and 8-OH-DPAT (HY-112061) (0.1 mg/kg; subcutaneous injection) can increase the percentage of mounts, intromissions, and ejaculations in rats, shorten the ejaculation latency, and reduce the number of intromissions[1].

[IC 50]

α2-adrenergic receptor: 9.5 (pKi); α1-adrenergic receptor: 5.3 (pKi)
[References]

[1] Tallentire D, et al. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996;118(1):63-72. DOI:10.1111/j.1476-5381.1996.tb15367.x
119942-75-5 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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